On the other hand, it was revealed by the Naruto Manga chapter 427 that Tsunade and Pain actually knew each other. It seems that they were friend.

But I think, it was because they meet each other long ago when Pain is still a child. That was the time when Jiraiya-Sama got a break from the team of the Sannin and trained Pain and his two other friends.

So, through this chapter, we can now expect a very exciting fight between Tsunade and Pain. It’s like Mannyh Pacquiao vs Oscar De la Hoya.

From here, I think Tsunade will be killed by Pain. However, before the death of Tsunade, she will declare Naruto as the 6th Hokage of Konoha.

Remember that Pain and the Paper lady is much stronger member of Akatsuki compared to other members except with Uchiha Madara. No one in the Konoha Village can face them but Tsunade alone because Tsunade was believed to be the strongest Konoha ninja of that time. I mentioned Tsunade was believed to be the strongest because Tsunade is not already the strongest konoha ninja of this time.

Now, since Tsunade doesn’t know the personality of Pain, then I’m sure she will be killed by Pain just like what happened to Jiraiya.

The latest chapter revealed that Tsunade ordered a Konoha messenger to summon Naruto. Naruto in the other hand just finished the Sage training from the King of Frogs.

So, during the battle of Konoha against Akatsuki, Tsunade will appoint Naruto as the Konoha’s 6th Hokage. This is the right time for him to be appointed to that position knowing that Naruto is now the strongest Konoha ninja of this time.